BAY 11-7085 | B2329

An irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It prevents gene expression that is regulated through the classical pathway of NF-κB activation and thus blocks apoptosis, cell adhesion, and inflammation.

BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It prevents gene expression that is regulated through the classical pathway of NF-κB activation and thus blocks apoptosis, cell adhesion, and inflammation.

B2329 | BAY 11-7085 DataSheet

Alternate Name/Synonyms: (E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile,3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile

Appearance: White solid

Formulation:

CAS Number: 196309-76-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₃H₁₅NO₂S

Molecular Weight: 249.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: >20 mg/ml (EtOH) in 0,>20 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An irreversible inhibitor of TNF-α-induced IκBα phosphorylation

MDL Number: MFCD01862602

PubChem CID: 5353432

SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N

InChi: InChI=1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+

InChi Key: VHKZGNPOHPFPER-ONNFQVAWSA-N