BAY-2402234 | B3328

BAY-2402234 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 1.2 nM). It induces upregulation of the cell differentiation marker CD11b in MOLM-13 and HEL acute myeloid leukemia (AML) cells (EC50s = 3.16 and 0.96 nM, respectively) and inhibits the proliferation of nine leukemia cell lines (IC50s = 0.08-8.2 nM). BAY-2402234 induces cell cycle arrest at the G2/M phase and apoptosis in TF-1 cells in a concentration-dependent manner.

BAY-2402234 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 1.2 nM). It induces upregulation of the cell differentiation marker CD11b in MOLM-13 and HEL acute myeloid leukemia (AML) cells (EC50s = 3.16 and 0.96 nM, respectively) and inhibits the proliferation of nine leukemia cell lines (IC50s = 0.08-8.2 nM). BAY-2402234 induces cell cycle arrest at the G2/M phase and apoptosis in TF-1 cells in a concentration-dependent manner.

B3328 | BAY-2402234 DataSheet

Alternate Name/Synonyms: BAY2402234 N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-5-fluoro-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]-benzamide

Appearance: Solid

Formulation:

CAS Number: 2225819-06-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₈ClF₅N₄O₄

Molecular Weight: 520.8

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >20 mg/ml Ethanol ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A dihydroorotate dehydrogenase (DHODH) inhibitor

MDL Number:

PubChem CID: 134470179

SMILES: O=C1N(C2=CC(O[C@@H](C)C(F)(F)F)=C(C=C2F)C(NC3=C(C=CC=C3F)Cl)=O)N=C(CO)N1CC

InChi: InChI=1S/C21H18ClF5N4O4/c1-3-30-17(9-32)29-31(20(30)34)15-8-16(35-10(2)21(25,26)27)11(7-14(15)24)19(33)28-18-12(22)5-4-6-13(18)23/h4-8,10,32H,3,9H2,1-2H3,(H,28,33)/t10-/m0/s1

InChi Key: KNVJMHHAXCPZHF-JTQLQIEISA-N