BAY 43-9006, Free base | 2142

A free base form of BAY 43-9006 (Sorafenib) (Cat. No. 1594-25,100). Acts as an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).

A free base form of BAY 43-9006 (Sorafenib) (Cat. No. 1594-25,100). Acts as an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).

2142 | BAY 43-9006, Free base DataSheet

Alternate Name/Synonyms: Sorafenib

Appearance: Off-white solid

Formulation: N/A

CAS Number: 284461-73-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₆ClF₃N₄O₃

Molecular Weight: 464.82

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (200 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Raf kinase inhibitor

MDL Number: MFCD06411450

PubChem CID: 216239

SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChi:

InChi Key: MLDQJTXFUGDVEO-UHFFFAOYSA-N