BAY 80-6946 | B1267

BAY 80-6946 is a highly selective and potent pan-class I PI3K inhibitor with sub-nanomolar IC₅₀s against PI3Kα and PI3Kδ. BAY 80-6946 displays preferential inhibition (about 10-fold) of AKT phosphorylation by PI3Kα compared with PI3Kβ in cells. Shows anticancer properties.

BAY 80-6946 is a highly selective and potent pan-class I PI3K inhibitor with sub-nanomolar IC₅₀s against PI3Kα and PI3Kδ. BAY 80-6946 displays preferential inhibition (about 10-fold) of AKT phosphorylation by PI3Kα compared with PI3Kβ in cells. Shows anticancer properties.

B1267 | BAY 80-6946 DataSheet

Alternate Name/Synonyms: 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide; Copanlisib

Appearance: Crystaline solid

Formulation: N/A

CAS Number: 1032568-63-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₂₈N₈O₄

Molecular Weight: 480.52

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A pan-class I PI3K inhibitor

MDL Number: N/A

PubChem CID: 24989044

SMILES: COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5

InChi: nChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)

InChi Key: PZBCKZWLPGJMAO-UHFFFAOYSA-N