BBT-594 | B2114

BBT-594 is a potent and selective RET and JAK2 inhibitor. It impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. Displays potent anticancer activity.

BBT-594 is a potent and selective RET and JAK2 inhibitor. It impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. Displays potent anticancer activity.

B2114 | BBT-594 DataSheet

Alternate Name/Synonyms: 5-((6-acetamidopyrimidin-4-yl)oxy)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)indoline-1-carboxamide; NVP-BBT594

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 882405-89-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₀F₃N₇O₃

Molecular Weight: 569.59

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective RET and JAK2 inhibitor.

MDL Number: N/A

PubChem CID: 59596344

SMILES: CC(=O)NC1=CC(=NC=N1)OC2=CC3=C(C=C2)N(CC3)C(=O)NC4=CC(=C(C=C4)CN5CCN(CC5)C)C(F)(F)F

InChi: InChI=1S/C28H30F3N7O3/c1-18(39)34-25-15-26(33-17-32-25)41-22-5-6-24-19(13-22)7-8-38(24)27(40)35-21-4-3-20(23(14-21)28(29,30)31)16-37-11-9-36(2)10-12-37/h3-6,13-15,17H,7-12,16H2,1-2H3,(H,35,40)(H,32,33,34,39)

InChi Key: VQLNKQZLPGLOSI-UHFFFAOYSA-N