BCAP31 Antibody (Center) [APR04594G]

BCAP31 Antibody (Center) [APR04594G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This BCAP31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-147 amino acids from the Central region of human BCAP31.

Cellular Localisation: Endoplasmic reticulum membrane; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex (PubMed:9396746) . Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40 (PubMed:31206022)

Molecular Weight: 27992

Clone: Polyclonal

Gene Name: BCAP31

Gene ID: 10134

Function: Functions as a chaperone protein (PubMed:9396746, PubMed:18287538) . Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538) . Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538) . Also serves as a cargo receptor for the export of transmembrane proteins (By similarity) . Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022) . In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022) . May be involved in CASP8-mediated apoptosis (PubMed:10958671) .

Summary: Tissue Location: Ubiquitous. Highly expressed in neurons and discrete endocrine cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IHC-P

Dilution: IHC-P--1:100~500 WB--1:1000

Synonyms: B-cell receptor-associated protein 31, BCR-associated protein 31, Bap31, 6C6-AG tumor-associated antigen, Protein CDM, p28, BCAP31, BAP31, DXS1357E