BCCIP Antibody | 23-675

BCCIP Antibody | 23-675 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1) .

Research Area: Cancer, Cell Cycle, Chemokines & Cytokines, Immunology

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:100 - 1:200

Specificiy: N/A

Positive Control 1: SKOV3

Positive Control 2: HeLa

Positive Control 3: Mouse brain

Positive Control 4: Mouse liver

Positive Control 5: Mouse small intestine

Positive Control 6: N/A

Molecular Weight: Observed: 50kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: TOK-1, TOK1, BRCA2 and CDKN1A-interacting protein, BCCIPalpha, BCCIPbeta, BRCA2 and Cip1/p21 interacting protein, TOK-1alpha, TOK-1beta, cdk inhibitor p21 binding protein, p21- and CDK-associated protein 1, protein TOK-1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.