BCl-2 Inhibitor GX15-070 | 2040

Cell-permeable. A small molecule pan–Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2–, Bcl-xl–, Bcl-w–, and Mcl-1–mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells.

BCl-2 Inhibitor GX15-070 is a small molecule pan–Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2–, Bcl-xl–, Bcl-w–, and Mcl-1–mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells.

2040 | BCl-2 Inhibitor GX15-070 DataSheet

Alternate Name/Synonyms: (Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate

Appearance: Off-white solid

Formulation: N/A

CAS Number: 803712-67-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₉N₃O

Molecular Weight: 317.38

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>80 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Bcl-2 inhibitor

MDL Number: N/A

PubChem CID: 16681698

SMILES: CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O

InChi: InChI=1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23- 19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21,23H,1-3H3;1H3,(H,2,3, 4)/b18-17-,19-10-;

InChi Key: ZVAGBRFUYHSUHA-LZOXOEDVSA-N