BW
Bcl-X (phospho-S62) polyclonal Antibody | BS4025
- SKU:
- BW-BS4025
- Availability:
- Usually ships in 5 working days
Description
Bcl-X (phospho-S62) polyclonal Antibody | BS4025 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:150
Background: Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3-dependent cell line, and Bax also counters the death repressor activity of Bcl-2. Bcl-x, one of several additional proteins with sequence homology to Bcl-2, is expressed as Bcl-xL, a 233 amino acid protein with 43% sequence identity with Bcl-2 that suppresses cell death, and Bcl-xS, a shorter variant that is 178 amino acids in length and lacks a 63 amino acid region (amino acids 126-188) found in Bcl-xL and which functions as a dominant inhibitor of Bcl-2. A further apoptosis-inducing protein, Bad, dimerizes both with Bcl-xL and to a lesser extent with Bcl-2, thus displacing Bax and inducing apoptosis
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-Bcl-X (S62) polyclonal Antibody detects endogenous levels of Bcl-X protein only when phosphorylated at Ser62.
Molecular Weight: Predicted band size : 26 kDa Observed band size : 39 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; BCL2L1; BCL2L; BCLX; Bcl-xL; Bcl-XS; BclxL; BclXS
Immunogen: Synthetic phosphopeptide derived from human Bcl-X around the phosphorylation site of Serine 62.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Cell Cycle G2 M DNA Damage Signaling Pathway,