BCL-x Polyclonal Antibody | E-AB-30640

BCL-x Polyclonal Antibody | E-AB-30640 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Apoptosis regulator Bcl X, Apoptosis regulator Bcl-X, Apoptosis regulator BclX, B cell lymphoma 2 like, B2CL1, Bcl 2 like 1 protein, Bcl X, Bcl xL, BCL XL/S, Bcl xS, Bcl-2-like protein 1, Bcl2 Like 1, Bcl2 related gene, Bcl2-L-1, BCL2L, Bcl2l1, BCLX, BclXL, BclXs, DKFZp781P2092, PPP1R52, Protein phosphatase 1 regulatory subunit 52

Application: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Metabolism, Signal Transduction

Background: Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of Thr47.

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 26 kDa

Molecular Weight(Observed): 30 kDa