Bcl-xL Antibody [7B2.5] (Biotin) | 99-618

Bcl-xL Antibody [7B2.5] (Biotin) | 99-618 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat, Rhesus

Homology: N/A

Immunogen: Recombinant human Bcl-xS

Research Area: Transcription, Cancer

Tested Application: IHC-P, IHC-Fr, ICC, Flow, IP

Application: Bcl-xL Antibody [7B2.5] for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, western blotting, and immunoprecipitation assays.

Specificiy: Bcl-xL

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [7B2.5]

Isotype: IgG3

Conjugate: Biotin

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: 0.1 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Apoptosis regulator Bcl-X, Bcl-2-like 1 protein, BCL2L1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Bcl-xL is a 29 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. It is found in both soluble and membrane fractions of cellular lysates. Like Bcl-2, Bcl-xL has been demonstrated to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. While formation of heterodimers with the apoptosis-enhancing protein, Bax does not block the apoptosis-suppressing property of Bcl-xL, heterodimerization with Bad effectively inhibits the protective function of Bcl-xL.