BCL11B Antibody (Center) [APR03503G]

BCL11B Antibody (Center) [APR03503G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This BCL11B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-334 amino acids from the Central region of human BCL11B.

Cellular Localisation: Nucleus.

Molecular Weight: 95519

Clone: Polyclonal

Gene Name: BCL11B

Gene ID: 64919

Function: Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755) . Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4 (+) T-lymphocytes (PubMed:16809611) . Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity) . May also function in the P53-signaling pathway (By similarity) .

Summary: Tissue Location: Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:16000

Synonyms: B-cell lymphoma/leukemia 11B, BCL-11B, B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, BCL11B, CTIP2, RIT1