BCL3 Antibody | 7183

BCL3 Antibody | 7183 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Rabbit polyclonal BCL3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human BCL3.
The immunogen is located within amino acids 360 - 410 of BCL3.

Research Area: Cancer, Cell Cycle

Tested Application: E, WB

Application: BCL3 antibody can be used for detection of BCL3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 1210 - HEK293 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 50 kDa

Validation: N/A

Isoform: N/A

Purification: BCL3 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: BCL3 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: BCL3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: BCL3 Antibody: BCL4, D19S37, BCL4, B-cell lymphoma 3 protein, Proto-oncogene BCL3, BCL-3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: BCL3 Antibody: The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-κ-B target genes. BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-κ-B proteins. The expression of this gene can be induced by NF-κ-B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-κ-B. It contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.