BD-1, human recombinant | 4506

The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Defensin-1 (BD-1) is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. BD-1 has close proximity to Defensin -1 and has been implicated in the pathogenesis of cystic fibrosis. Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human BD-1 mRNA expression and higher human BD-2 and human BD-3 mRNA expression. Defensin is highly expressed by epithelial cells. BD-1 may play a role in the pathogenesis of severe sepsis. Variation in human BD-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human BD-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. Recombinant human Defensin-1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 47 amino acids and having a molecular mass of 5 kDa.

4506 | BD-1 human recombinant DataSheet

Biomolecule/Target: BD-1

Synonyms: -defensin 1, BD-1, Defensin 1, hBD-1, HBD1, HBP1, DEFB1, HBD-1, HBP-1, DEFB101, DEFB-1, MGC51822

Alternates names: Small inducible cytokine A19, CCL19, Macrophage inflammatory protein 3 , MIP-3- , EBI1-ligand chemokine, ELC, chemokine exodus-3, CK -11, chemokine (C-C motif) ligand 19, CKb11, MIP3B, MIP-3b, SCYA19, MGC34433, Beta-chemokine exodus-3, CK beta-11, Epstein-Barr virus-induced molecule 1 ligand chemokine

Taglines: An antimicrobial peptide

NCBI Gene ID #: 24047

NCBI Gene Symbol: CCL19

Gene Source: Human

Accession #: O70460

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract human mature dendritic cells using a concentration of 10-100 ng/ml.

Results: 0.1-1 µg/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 9.2 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from a concentrated (1 mg/ml) solution containing 20 mM PBS pH-7.4 and 130 mM sodium chloride

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A