BEC | 2359

A potent, slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 µM. It is also a potent inhibitor of human arginase II with Ki values of 0.31 µM and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM.

BEC is a potent, slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 µM. It is also a potent inhibitor of human arginase II with Ki values of 0.31 µM and 30 nM at pH 7.5 and 9.5, respectively.

2359 | BEC DataSheet

Alternate Name/Synonyms: S-​(2-​boronoethyl)-​L-​cysteine

Appearance: White solid

Formulation: N/A

CAS Number: 63107-40-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅H₁₂BNO₄S

Molecular Weight: 193.03

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: PBS, pH 7.2 (~ 5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent arginase inhibitor

MDL Number: N/A

PubChem CID: 9877608

SMILES: B(CCSCC(C(=O)O)N)(O)O

InChi: InChI=1S/C5H12BNO4S/c7-4(5(8)9)3-12-2-1-6(10)11/h4,10-11H,1-3,7H2,(H,8,9)/t4-/m0/s1

InChi Key: OTJHLDXXJHAZTN-BYPYZUCNSA-N