Benazepril hydrochloride | B2138

Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat. It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC₅₀ = 2 nM). Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat. It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC₅₀ = 2 nM). Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

B2138 | Benazepril hydrochloride DataSheet

Alternate Name/Synonyms: (3S)-3-[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid Hydrochloride; CGS 14824A

Appearance: White solid

Formulation: N/A

CAS Number: 86541-74-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₈N₂O₅·HCl

Molecular Weight: 460.96

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml) or H₂O (20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent angiotensin converting-Enzyme (ACE) inhibitor

MDL Number: MFCD00895734

PubChem CID: 5362123

SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl

InChi: InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

InChi Key: VPSRQEHTHIMDQM-FKLPMGAJSA-N