Berbamine dihydrochloride | 2520

Berbemine is a naturally occurring alkaloid that displays several biological properties. Berbamine potently suppresses liver cancer cell proliferation and induces cancer cell death by targeting Ca²⁺/calmodulin-dependent protein kinase II (CAMKII). Also acts as a novel inhibitor of NF-kappaB activity with remarkable anti-myeloma efficacy.

Berbemine is a naturally occurring alkaloid that displays several biological properties. Berbamine potently suppresses liver cancer cell proliferation and induces cancer cell death by targeting Ca²⁺/calmodulin-dependent protein kinase II (CAMKII). Also acts as a novel inhibitor of NF-kappaB activity with remarkable anti-myeloma efficacy.

2520 | Berbamine dihydrochloride DataSheet

Alternate Name/Synonyms: Berbenine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 6078-17-7

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₇H₄₂Cl₂N₂O₆

Molecular Weight: 681.65

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Ca²⁺/calmodulin-dependent kinase type II inhibitor

MDL Number: MFCD11982910

PubChem CID: 16217067

SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl

InChi: InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;2*1H/t28-,29+;;/m0../s1

InChi Key: USRXDYNDPPUBSG-KKXMJGKMSA-N