Berberine Chloride | 1830

An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in acute lymphoblastic leukemia (ALL) cells with both MDM2 overexpression and a wild-type (wt)-p53, whereas no pro-apoptotic effect was detected in ALL cells that were negative for MDM2 and wt-p53.

Berberine is an isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines.

1830 | Berberine Chloride DataSheet

Alternate Name/Synonyms: Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium

Appearance: Yellow to orange solid

Formulation: N/A

CAS Number: 633-65-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₈ClNO₄

Molecular Weight: 371.81

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: MeOH (50 mg/ml) or Water (~ 2 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: MFCD00011939

PubChem CID: 12456

SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

InChi: InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

InChi Key: VKJGBAJNNALVAV-UHFFFAOYSA-M