Beta 2 Microglobulin, Human Urine | P1432

B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. For the diagnosis of multiple myeloma, the serum β2-microglobulin level is one of the prognostic factors incorporated into the International Staging System. The serum β2-microglobulin level is elevated (>2.7 mg/L) in 75% of patients at the time of diagnosis.

P1432 | Beta 2 Microglobulin, Human Urine DataSheet

Biomolecule/Target :

Synonyms: B2M, BMG, beta-2M

Alternates names: B2M, BMG, beta-2M

Taglines:

NCBI Gene ID #: 567

NCBI Gene Symbol: B2M

Gene Source: Human

Accession #: P61769

Recombinant: False

Source: Human urine

Purity by SDS-PAGE: >98%

Assay: SDS-PAGE.

Purity:

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Unit Definition:

Molecular Weight: 12 kDa

Concentration:

Appearance: Liquid protein

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence:

Handling: Centrifuge the vial prior to opening.

Usage: