Beta Catenin Antibody [5H10] | 33-621

Beta Catenin Antibody [5H10] | 33-621 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Chicken

Homology: N/A

Immunogen: A C-terminal 100 amino acid segment from chicken beta-Catenin was used as the immunogen for the Beta Catenin antibody.

Research Area: Cancer, Neuroscience, Signal Transduction

Tested Application: IHC-P, Flow, IF, WB

Application: Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Immunofluorescence: 1-2 ug/ml
WB: 0.5-1 ug/ml
IHC (FFPE) : 1-2 ug/ml
Optimal dilution of the Beta Catenin antibody to be determined by the researcher.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Protein G affinity chromatography

Clonality: Monoclonal

Clone: 5H10

Isotype: IgG1, kappa

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Concentration: 0.2 mg/mL

Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.

Alternate Name: Catenin beta-1, Beta-catenin, CTNNB1, CTNNB

User Note: Optimal dilutions for each application to be determined by the researcher

BACKGROUND: Beta Catenin is a dual function protein, regulating the coordination of cell���cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. Beta catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to gamma-Catenin, also known as plakoglobin. Beta-Catenin is widely expressed in many tissues. In cardiac muscle, it localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocyte. [Wiki]