BEZ235 (NVP-BEZ235) | 1626

Orally active PI-3 kinase inhibitor; Dual PI3K/mTOR inhibition; BEZ235 showed high target specificity and demonstrated anti-proliferative activity against tumor cell lines in animal models of cancer.

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.

1626 | BEZ235 (NVP-BEZ235) DataSheet

Alternate Name/Synonyms: NVP-BEZ235

Appearance: Off-white to pale yellow solid

Formulation: N/A

CAS Number: 915019-65-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₂₃N₅O

Molecular Weight: 469.55

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (10 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A PI3 Kinase inhibitor

MDL Number: MFCD10565944

PubChem CID: 11977753

SMILES: CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

InChi: InChI=1S/C30H23N5O/c1-30(2, 18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16- 21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3

InChi Key: JOGKUKXHTYWRGZ-UHFFFAOYSA-N