BG-45 | B1866

BG-45 is a potent HDAC class I inhibitor with selectivity for HDAC3 (IC₅₀ = 289 nM) over HDAC1, 2. BG45 does not inhibit HDAC6. BG-45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.

BG-45 is a potent HDAC class I inhibitor with selectivity for HDAC3 (IC₅₀ = 289 nM) over HDAC1, 2. BG45 does not inhibit HDAC6. BG-45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.

B1866 | BG-45 DataSheet

Alternate Name/Synonyms: N-(2-Aminophenyl)pyrazine-2-carboxamide

Appearance: White to of-white solid

Formulation: N/A

CAS Number: 926259-99-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₁H₁₀N₄O

Molecular Weight: 214.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent HDAC class I inhibitor

MDL Number: N/A

PubChem CID: 16773791

SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=NC=CN=C2

InChi: InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16)

InChi Key: LMWPVSNHKACEKW-UHFFFAOYSA-N