BGLAP polyclonal Antibody | BS60987

BGLAP polyclonal Antibody | BS60987 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Bone g-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BGLAP polyclonal Antibody detects endogenous levels of BGLAP protein.

Molecular Weight: ~ 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Osteocalcin; Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein; BGLAP

Immunogen: A synthetic peptide corresponding to residues in Human BGLAP.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A