BH3I-1 | B1277

BH3I-1 is a cell-permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis. It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 µM, respectively. BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.

BH3I-1 is a cell-permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis. It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 µM, respectively. BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.

B1277 | BH3I-1 DataSheet

Alternate Name/Synonyms: 5-[(4-bromophenyl)methylene]-a-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid

Appearance: Yellow solid

Formulation: N/A

CAS Number: 300817-68-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₄BrNO₃S₂

Molecular Weight: 400.31

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Bcl-2 family inhibitor

MDL Number: MFCD03453544

PubChem CID: 6090108

SMILES: CC(C)C(C(=O)O)N1C(=O)C(=CC2=CC=C(C=C2)Br)SC1=S

InChi: InChI=1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+

InChi Key: COHIEJLWRGREHV-YRNVUSSQSA-N