BHMT monoclonal Antibody | MB9090

BHMT monoclonal Antibody | MB9090 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: N/A

Application Range: WB:1:1,000-1:5,000 ICC:1:50 IHC:1:50-1:200 FC:1:50-1:100

Background: Betaine-homocysteine methyltransferase (BHMT) is a zinc-dependent cytosolic protein that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. BHMT is highly expressed in rat liver, and its expression is regulated by dietary methionine and choline. In humans, S-adenosylmethionine (SAM) down-regulates BHMT expression by inducing NFκB, which acts as a repressor for the BHMT gene. Lowered BHMT levels can lead to ER (endoplasmic reticulum) stress. Mutations in the gene encoding for BHMT may lead to hyperhomocysteinemia, a medical condition characterized by abnormally large amounts of homocysteine in the blood which may be a risk factor for cardiovascular and cerebrovascular diseases.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: BHMT monoclonal Antibody detects endogenous levels of BHMT protein.

Molecular Weight: 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: BHMT, Betaine homocysteine methyltransferase, Betaine homocysteine S methyltransferase 1, Betaine homocysteine S methyltransferase, Betainehomocysteine S-methyltransferase 1, BHMT, BHMT1, BHMT1, EC 2.1.1.5, Epididymis secretory sperm binding protein Li 61p, HEL S 61p,

Immunogen: Recombinant protein.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProG affinity purified.

Pathway: