BI-2536 | 2370

BI-2536 is a potent, selective inhibitor of polo-like kinase 1 (PLK1) (IC₅₀ = 0.83 nM). It blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC₅₀ of 3.5 nM and 9.0 nM, respectively. BI-2536 potently causes a mitotic arrest and induces apoptosis in human cancer cell lines of diverse tissue origin.

BI-2536 is a potent, selective inhibitor of polo-like kinase 1 (PLK1) (IC₅₀ = 0.83 nM).

2370 | BI-2536 DataSheet

Alternate Name/Synonyms: (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 755038-02-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₉N₇O₃

Molecular Weight: 521.65

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml) or Ethanol (~ 100 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A selective polo-like kinase 1 (PLK1) inhibitor

MDL Number: MFCD10565924

PubChem CID: 11364421

SMILES: CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

InChi: InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1

InChi Key: XQVVPGYIWAGRNI-JOCHJYFZSA-N