BI-409306 | B2377

BI-409306 is a potent and selective PDE9A inhibitor (IC50 = 52 nM). Displays weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 > 10 µM). Potentially could be useful for the treatment of Alzheimer’s disease and Schizophrenia.

BI-409306 is a potent and selective PDE9A inhibitor (IC50 = 52 nM). Displays weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 > 10 µM). Potentially could be useful for the treatment of Alzheimer’s disease and Schizophrenia.

B2377 | BI-409306 DataSheet

Alternate Name/Synonyms: 6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, BI409306, SUB 166499

Appearance: Crystalline solid

Formulation:

CAS Number: 1189767-28-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₆H₁₇N₅O₂

Molecular Weight: 311.35

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective PDE9A inhibitor

MDL Number:

PubChem CID: 44252845

SMILES: C1COCCC1N2C3=NC(=NC(=O)C3=CN2)CC4=CC=CC=N4

InChi: InChI=1S/C16H17N5O2/c22-16-13-10-18-21(12-4-7-23-8-5-12)15(13)19-14(20-16)9-11-3-1-2-6-17-11/h1-3,6,10,12,18H,4-5,7-9H2

InChi Key: CKMLRBFEHNMVHO-UHFFFAOYSA-N