BI-847325 | B1589

BI-847325 is an ATP-competitive dual inhibitor of MEK and Aurora kinases. Potent inhibition of MEK1/2 and Aurora A/B kinases by BI-847325 was demonstrated in enzymatic and cellular assays.

BI-847325 is an ATP-competitive dual inhibitor of MEK and Aurora kinases. Potent inhibition of MEK1/2 and Aurora A/B kinases by BI-847325 was demonstrated in enzymatic and cellular assays.

B1589 | BI-847325 DataSheet

Alternate Name/Synonyms: (Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1207293-36-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₉H₂₈N₄O₂

Molecular Weight: 464.57

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: an ATP-competitive dual inhibitor of MEK and Aurora kinases.

MDL Number: N/A

PubChem CID: 54577344

SMILES: CCNC(=O)C#CC1=CC2=C(C=C1)C(=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN(C)C)C(=O)N2

InChi: InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8-6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30,34)(H,32,35)/b28-27-

InChi Key: FLBNLJLONKAPLR-DQSJHHFOSA-N