BIBF-0775 | B2461

BIBF-0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor (IC₅₀ = 34 nM).

BIBF-0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor (IC₅₀ = 34 nM).

B2461 | BIBF-0775 DataSheet

Alternate Name/Synonyms: BIBF0775; (3Z)-N-Ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide

Appearance: Crystalline solid

Formulation:

CAS Number: 334951-90-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₃₄N₃₄O₂

Molecular Weight: 494.64

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A transforming growth factor β receptor I (TGFβRI) inhibitor

MDL Number:

PubChem CID: 349759620

SMILES: O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(C3=CC=CC=C3)\NC4=CC=C(CN5CCCCC5)C=C4)N(CC)C

InChi: InChI=1S/C31H34N4O2/c1-3-34(2)31(37)24-14-17-26-27(20-24)33-30(36)28(26)29(23-10-6-4-7-11-23)32-25-15-12-22(13-16-25)21-35-18-8-5-9-19-35/h4,6-7,10-17,20,32H,3,5,8-9,18-19,21H2,1-2H3,(H,33,36)/b29-28-

InChi Key: MUSRTIADFPCYTQ-ZIADKAODSA-N