BIBF1120 | 2167

BIBF1120 is a triple angiokinase inhibitor. It blocks signaling through vascular endothelial growth factor receptors (VEGFR; IC₅₀ values of 13 to 34 nM), platelet-derived growth factor receptors (PDGFR; IC₅₀ values of 59 to 65 nM), and fibroblast growth factor receptors (FGFR; IC₅₀ values of 37 to 610 nM).

BIBF1120 is a triple angiokinase inhibitor. It blocks signaling through vascular endothelial growth factor receptors (VEGFR; IC₅₀ values of 13 to 34 nM), platelet-derived growth factor receptors (PDGFR; IC₅₀ values of 59 to 65 nM), and fibroblast growth factor receptors (FGFR; IC₅₀ values of 37 to 610 nM).

2167 | BIBF1120 DataSheet

Alternate Name/Synonyms: (Z)-​methyl 3-​(((4-​(N-​methyl-​2-​(4-​methylpiperazin-​1-​ yl)acetamido)phenyl)amino)(phenyl)methylene)-​2-​oxoindoline-​6-​ carboxylate

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 928326-83-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₃₃N₅O₄

Molecular Weight: 539.62

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~ 6 mg/ml) or EtOH (~ 3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A triple angiokinase inhibitor

MDL Number: MFCD11974012

PubChem CID: 9809715

SMILES: CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)NC(=C3C4=C(C=C(C=C4)C(=O)OC)NC3=O)C5=CC=CC=C5

InChi: InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-

InChi Key: XZXHXSATPCNXJR-ZIADKAODSA-N