BIBR-1532 | B3082

BIBR-1532 is a highly potent mixed-type non-competitive inhibitor of telomerase. It inhibits telomerase in a dose-dependent manner, with an IC₅₀ of 93 nM. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. It induces senescence in cancer cells.

BIBR-1532 is a highly potent mixed-type non-competitive inhibitor of telomerase. It inhibits telomerase in a dose-dependent manner, with an IC₅₀ of 93 nM. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. It induces senescence in cancer cells.

B3082 | BIBR-1532 DataSheet

Alternate Name/Synonyms: (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid; 2-{[(2e)-3-(Naphthalen-2-Yl)but-2-Enoyl]amino}benzoic Acid; 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid; Telomerase Inhibitor X

Appearance: Off-white solid

Formulation:

CAS Number: 321674-73-1

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₁H₁₇NO₃

Molecular Weight: 331.26

Cell-Permeable?: TRUE

Purity: ≥ 98%

Solubilities: ~30 mg/ml in DMSO or DMF, ~1 mg/ml in ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of telomerase

MDL Number:

PubChem CID: 9927531

SMILES: CC(=CC(=O)NC1=CC=CC=C1C(=O)O)C2=CC3=CC=CC=C3C=C2

InChi: InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+

InChi Key: PGFQXGLPJUCTOI-WYMLVPIESA-N