BIBS39 | B1071

BIBS-39 is a novel, nonpeptide angiotensin II receptor antagonist that displays antihypertensive activity. In contrast to the angiotensin II receptor subtype 1 (AT1) selective drug DuP 753, BIBS-39 also displays affinity for the angiotensin II receptor subtype 2. BIBS 39 displaces [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor.

BIBS-39 is a novel, nonpeptide angiotensin II receptor antagonist that displays antihypertensive activity. In contrast to the angiotensin II receptor subtype 1 (AT1) selective drug DuP 753, BIBS-39 also displays affinity for the angiotensin II receptor subtype 2.

B1071 | BIBS39 DataSheet

Alternate Name/Synonyms: 4'-((2-Butyl-6-(((cyclohexylamino)carbonyl)amino)-1H-benzimidazo-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 133085-33-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₆N₄O₃

Molecular Weight: 524.66

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A novel, nonpeptide angiotensin II receptor antagonist, showing antihypertensive activity

MDL Number:

PubChem CID: 131590

SMILES: CCCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2)NC(=O)NC5CCCCC5

InChi: InChI=1S/C32H36N4O3/c1-2-3-13-30-35-28-19-18-25(34-32(39)33-24-9-5-4-6-10-24)20-29(28)36(30)21-22-14-16-23(17-15-22)26-11-7-8-12-27(26)31(37)38/h7-8,11-12,14-20,24H,2-6,9-10,13,21H2,1H3,(H,37,38)(H2,33,34,39)

InChi Key: OLQFKFSAJNUOPT-UHFFFAOYSA-N