BIBW2992 (Tovok) | 1616

BIBW-2992 is a potent irreversible EGFR/HER2 inhibitor. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC₅₀ values of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases and no additional inhibition of other kinases has been observed.

BIBW-2992 (Tovok) is a potent irreversible EGFR/HER2 inhibitor. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC₅₀ values of 0.5 nM and 14 nM, respectively.

1616 | BIBW2992 (Tovok) DataSheet

Alternate Name/Synonyms: Tovok, Afatinib

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 439081-18-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₅ClFN₅O₃

Molecular Weight: 485.94

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An EGFR/HER2 inhibitor

MDL Number: MFCD12407405

PubChem CID: 10184653

SMILES: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

InChi: InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34- 16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12, 14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1

InChi Key: ULXXDDBFHOBEHA-CWDCEQMOSA-N