BW
BID (phospho-S78) polyclonal Antibody | BS4297
- SKU:
- BW-BS4297
- Availability:
- Usually ships in 5 working days
Description
BID (phospho-S78) polyclonal Antibody | BS4297 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC
Application Range: IHC: 1:50~1:200
Background: BID, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-BID (S78) polyclonal Antibody detects endogenous levels of BID protein only when phosphorylated at Ser78.
Molecular Weight: ~ 22 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: BH3-interacting domain death agonist; p22 BID; BID; BH3-interacting domain death agonist p15; p15 BID; BH3-interacting domain death agonist p13; p13 BID;,BH3-interacting domain death agonist p11; p11 BID; BID
Immunogen: Synthetic phosphopeptide derived from human BID around the phosphorylation site of Serine 78.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: