Description
A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC₅₀ values of 0.06, 0.31, and 0.14 µM, respectively.
BIIB 021 is a synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27.
Alternate Name/Synonyms: 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 848695-25-0
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₁₄H₁₅ClN₆O
Molecular Weight: 318.76
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (~65 mg/ml) or EtOH (~3 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A potent Hsp90 inhibitor
MDL Number: MFCD15528939
PubChem CID: 16736529
SMILES: CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
InChi: InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
InChi Key: QULDDKSCVCJTPV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |