BIIE 0246 | B2424

BIIE 0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor (IC₅₀ = 15 nM). BIIE 0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors.

BIIE 0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor (IC₅₀ = 15 nM). BIIE 0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors.

B2424 | BIIE 0246 DataSheet

Alternate Name/Synonyms: N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide

Appearance: White solid

Formulation:

CAS Number: 246146-55-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₉H₅₇N₁₁O₆

Molecular Weight: 896.06

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Potent, selective non-peptide NPY Y2 receptor antagonist

MDL Number:

PubChem CID: 9811493

SMILES: C1CCC(C1)(CC(=O)NC(CCCN=C(N)N)C(=O)NCCN2C(=O)N(N(C2=O)C3=CC=CC=C3)C4=CC=CC=C4)CC(=O)N5CCN(CC5)C6C7=CC=CC=C7C(=O)NC8=CC=CC=C68

InChi: InChI=1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)/t40-,43?/m0/s1

InChi Key: RSJAXPUYVJKAAA-JPGJPTAESA-N