Bim (phospho-S69/S65) polyclonal Antibody | BS64039

Bim (phospho-S69/S65) polyclonal Antibody | BS64039 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins, and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long) . ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS and BimL, implying a unique role for BimEL in cell survival signaling.

Storage & Stability: Store at 4°C short term. Aliquot and store at -22°C long term. Avoid freeze-thaw cycles.

Specificity: p-Bim (S69/S65) polyclonal Antibody detects endogenous levels of human Bim protein only when phosphorylated at Ser69. This Antibody also recognizes mouse or rat Bim Protein when phosphorylated at Ser65.

Molecular Weight: ~ 25 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death; BCL2L11; BIM

Immunogen: A synthetic peptide corresponding to residues in Human Bim around the phosphorylation site of Ser69.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: PI3K AKT signaling,Insulin &Glucose Signaling,MTOR signaling,