Bisantrene dihydrochloride | B2736

Bisantrene dihydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. It intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin (Cat. No. 1527) in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance

Bisantrene dihydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. It intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin (Cat. No. 1527) in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance

B2736 | Bisantrene dihydrochloride DataSheet

Alternate Name/Synonyms: NSC 337766,N-[(E)-[10-[(E)-(4,5-dihydro-1H-imidazol-2-ylhydrazinylidene)methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;dihydrochloride

Appearance: Yellow to orange brown solid

Formulation:

CAS Number: 78186-34-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₄Cl₂N₈

Molecular Weight: 471.39

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~ 2 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antineoplastic agent and a DNA intercalator

MDL Number: MFCD01743164

PubChem CID: 6917792

SMILES: C1CN=C(N1)NN=CC2=C3C=CC=CC3=C(C4=CC=CC=C42)C=NNC5=NCCN5.Cl.Cl

InChi: InChI=1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;

InChi Key: KINULKKPVJYRON-PVNXHVEDSA-N