Bisindolylmaleimide I | 1945

Cell-permeable. A Potent and ATP-competitive protein kinase C (PKC) inhibitor (Ki = 10 nM). Also acts as a potent Glycogen synthase kinase-3 (GSK-3) inhibitor.

Bisindolylmaleimide I is a potent and ATP-competitive protein kinase C (PKC) inhibitor (Ki = 10 nM). Also acts as a potent Glycogen synthase kinase-3 (GSK-3) inhibitor.

1945 | Bisindolylmaleimide I DataSheet

Alternate Name/Synonyms: 3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide; GF 109203X; Gö 6850; BIM I

Appearance: Orange solid

Formulation: N/A

CAS Number: 133052-90-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₄N₄O₂

Molecular Weight: 412.49

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (~ 10 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A Potent and ATP-competitive protein kinase C (PKC) inhibitor

MDL Number: MFCD00236428

PubChem CID: 2396

SMILES: 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)

InChi: CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

InChi Key: QMGUOJYZJKLOLH-UHFFFAOYSA-N