Description
BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM)
BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1,800 nM, respectively).
Alternate Name/Synonyms: (Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
Appearance: Solid
Formulation: N/A
CAS Number: 334949-59-6 (or 1094614-84-2)
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C25H24N4O2
Molecular Weight: 412.493
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>45 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A MEK5 Inhibitor
MDL Number: N/A
PubChem CID: 53401092
SMILES: CN(CC1=CC(N/C(C2=CC=CC=C2)=C3C(NC4=C\3C=CC(C(N)=O)=C4)=O)=CC=C1)C
InChi: 1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)
InChi Key: FSZPIAXLCCQFCM-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |