BIX02188 | B1328

BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM)

BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1,800 nM, respectively).

B1328 | BIX02188 DataSheet

Alternate Name/Synonyms: (Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide

Appearance: Solid

Formulation: N/A

CAS Number: 334949-59-6 (or 1094614-84-2)

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C25H24N4O2

Molecular Weight: 412.493

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>45 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A MEK5 Inhibitor

MDL Number: N/A

PubChem CID: 53401092

SMILES: CN(CC1=CC(N/C(C2=CC=CC=C2)=C3C(NC4=C\3C=CC(C(N)=O)=C4)=O)=CC=C1)C

InChi: 1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)

InChi Key: FSZPIAXLCCQFCM-UHFFFAOYSA-N