BLU9931 | 9639

BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4. It potently inhibits FGFR4 activity (IC₅₀ = 3 nM), but only weakly inhibits FGFR1 (IC₅₀ = 591 nM), FGFR2 (IC₅₀ = 493 nM), and FGFR3 (IC₅₀ = 150 nM) activity.

BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4. It potently inhibits FGFR4 activity (IC₅₀ = 3 nM), but only weakly inhibits FGFR1 (IC₅₀ = 591 nM), FGFR2 (IC₅₀ = 493 nM), and FGFR3 (IC₅₀ = 150 nM) activity.

9639 | BLU9931 DataSheet

Alternate Name/Synonyms: N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1538604-68-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₂Cl₂N₄O₃

Molecular Weight: 509.38

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and irreversible small-molecule inhibitor of FGFR4

MDL Number: N/A

PubChem CID: 72710839

SMILES: CC1=C(C(=CC=C1)NC(=O)C=C)NC2=NC=C3C=C(C=CC3=N2)C4=C(C(=CC(=C4Cl)OC)OC)Cl

InChi: InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32)

InChi Key: TXEBNKKOLVBTFK-UHFFFAOYSA-N