BLZ945 | B1651

BLZ945 is a brain-penetrant CSF-1R kinase inhibitor. The biochemical IC50 for CSF-1R is 1 nM, which is >3200-fold higher than its affinity for other kinases.

BLZ945 is a brain-penetrant CSF-1R kinase inhibitor. The biochemical IC50 for CSF-1R is 1 nM, which is >3200-fold higher than its affinity for other kinases.

B1651 | BLZ945 DataSheet

Alternate Name/Synonyms: BLZ-945, BLZ945; BLZ 945; 4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide; 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide

Appearance: Solid

Formulation: N/A

CAS Number: 953769-46-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂N₄O₃S

Molecular Weight: 398.48

Cell-Permeable?: Yes

Purity: >98%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A brain-penetrant CSF-1R inhibitor

MDL Number: MFCD28142668

PubChem CID: 46184986

SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O

InChi: InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1

InChi Key: ADZBMFGQQWPHMJ-RHSMWYFYSA-N