BMAL1 Polyclonal Antibody | BS65640

BMAL1 Polyclonal Antibody | BS65640 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,

Application: IHC-P,

Application Range: IHC-P=1:100-500 

Background: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BMAL1 Polyclonal Antibody detects endogenous levels of BMAL1 protein.

Molecular Weight: 69kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ARNT like protein 1 brain and muscle; ARNTL; Aryl hydrocarbon receptor nuclear translocator like; Aryl hydrocarbon receptor nuclear translocator like protein 1; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic helix loop helix PAS orphan MOP3; bHLH PAS protein JAP3; bHLHe5; BMAL 1; BMAL1c; Brain and muscle ARNT like 1; cycle; JAP 3; JAP3; Member of PAS protein 3; Member of PAS superfamily 3; MOP3; PAS domain-containing protein 3; PASD 3; PASD3; TIC.

Immunogen: KLH conjugated synthetic peptide derived from human BMAL1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: