BML-284 | B1077

BML-284 is cell-permeable Wnt signaling pathway agonist. It mimics the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt signaling pathway due to activation of Wnt without inhibiting the activity of GSK-3β; it induces in vitro β-catenin and transcription factor (TCF) dependent transcriptional activity in 293T cells in a dose-dependent manner with an EC₅₀ of 700 nM.

BML-284 is cell-permeable Wnt signaling pathway agonist. It mimics the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt signaling pathway due to activation of Wnt without inhibiting the activity of GSK-3β; it induces in vitro β-catenin and transcription factor (TCF) dependent transcriptional activity in 293T cells in a dose-dependent manner with an EC₅₀ of 700 nM.

B1077 | BML-284 DataSheet

Alternate Name/Synonyms: 2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 853220-52-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₈N₄O₃

Molecular Weight: 350.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective activator of Wnt signaling

MDL Number: N/A

PubChem CID: 11210285

SMILES: COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4

InChi: InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)

InChi Key: FABQUVYDAXWUQP-UHFFFAOYSA-N