BMP-14 (GDF-5/CDMP-1), human recombinant | 4580

BMPs (bone morphogenetic proteins) belong to the TGF- superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-14 is a principal inhibitor of cartilage development and is predominantly expressed in long bone during human embryonic development. Recombinant human BMP-14 is a 27 kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.

4580 | BMP-14 GDF-5/CDMP-1 human recombinant DataSheet

Biomolecule/Target: BMP-14

Synonyms: Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14

Alternates names: -defensin 1, BD-1, Defensin 1, hBD-1, HBD1, HBP1, DEFB1, HBD-1, HBP-1, DEFB101, DEFB-1, MGC51822

Taglines: A protein involved in bone and cartilage development

NCBI Gene ID #: 1672

NCBI Gene Symbol: DEFB1

Gene Source: Human

Accession #: P60022

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: 98%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1 µg/ml.

Results: 1-2 µg/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 5.0 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Sterile filtered and lyophilized from 10 mM Sodium Citrate, pH 3.5.

Reconstitution Instructions: Reconstitute in dHO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A