BMP3 Antibody (C-term) [APR15152G]

BMP3 Antibody (C-term) [APR15152G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This BMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-347 amino acids from the C-terminal region of human BMP3.

Cellular Localisation: Secreted.

Molecular Weight: 53372

Clone: Polyclonal

Gene Name: BMP3

Gene ID: 651

Function: Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification (PubMed:11138004, PubMed:15269709) . Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways (PubMed:31665064) .

Summary: Tissue Location: Expressed in adult and fetal cartilage.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3, BMP3A