Description
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E.coli.
7304 | BMP8B human recombinant DataSheet
Biomolecule/Target: BMP8B
Synonyms: BMP8, OP2, Bone morphogenetic protein 8B
Alternates names: BMP8, OP2, Bone morphogenetic protein 8B
Taglines: Signaling molecule that can induce ectopic bone growth
NCBI Gene ID #: 1514
NCBI Gene Symbol: CTSL1
Gene Source: Human
Accession #: P07711
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 microgram of protein
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 18.1 kDa (162 aa, 264-402 aa + His tag), confirmed by MALDI-TOF.
Concentration: 1 mg/ml
Appearance: Liquid
Physical form description: 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol
Reconstitution Instructions: N/A
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MGSAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH