BMPR1A, human recombinant | 4881

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the Activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. The BMR1A is purified by proprietary chromatographic techniques.

4881 | BMPR1A human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: BMPR-1A, BMP-R1A, BMPR1A, BMR1A, CD292, CD-292

Alternates names: Scatter Factor (SF), Hepatopoietin (HPTA), HGF, HGFB, F-TCF

Taglines: A transmembrane serine/threonine kinases

NCBI Gene ID #: 3082

NCBI Gene Symbol: HGF

Gene Source: Human

Accession #: P14210

Recombinant: Yes

Source: Insect cells (Baculovirus)

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: 90%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: The ED, calculated by the dose-dependent proliferation of monkey 4MBr-5 indicator cells was found to be 20-40 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 80.017 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from sterile PBS.

Reconstitution Instructions: It is recommended to reconstitute the lyophilized Hepatocyte Growth Factor (HGF) in sterile 18M-cm¹ HO not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

Amino acid sequence: N/A