Description
BMS-794833 is a potent, ATP-competitive inhibitor of Met and VEGFR2 with IC₅₀ of 1.7 nM and 15 nM, respectively. It also inhibits Ron, Axl, and Flt-3 with IC₅₀ values <3 nM.
BMS-794833 is a potent, ATP-competitive inhibitor of Met and VEGFR2 with IC₅₀ of 1.7 nM and 15 nM, respectively. It also inhibits Ron, Axl, and Flt-3 with IC₅₀ values <3 nM.
Alternate Name/Synonyms: N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1174046-72-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₁₅ClF₂N₄O₃
Molecular Weight: 468.84
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP-competitive inhibitor of Met and VEGFR2
MDL Number: N/A
PubChem CID: 44155856
SMILES: C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F
InChi: InChI=1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,31)(H,30,32)
InChi Key: PDYXPCKITKHFOZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
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