BMS-986253, HuMax-IL8, HuMax-Inflam/MDX018 Antibody, Monoclonal | 21-852

BMS-986253, HuMax-IL8, HuMax-Inflam/MDX018 Antibody, Monoclonal | 21-852 | Gentaur UK, US & Europe Distribution

Product Type: Primary Antibodies

Category: Primary Antibodies, Monoclonal Antibodies

Research Area: Drug Analogues

Type: Monoclonal

Host Species: N/A

Reactivity Species: N/A

Homology: N/A

Immunology: Humanized / IL-8 (Granulocyte chemotactic protein 1, Monocyte-derived neutrophil-activating peptide, IL-8 (1-77), IL-8 (9-77), Monocyte-derived neutrophil chemotactic factor, IL-8 (7-77), (Ser-IL-8) 72, GCP/IL-8 protein V, MONAP, C-X-C motif chemokine 8, GCP/IL-8 protein I, Neutrophil-ac ) [Homo sapiens]

Tested Application: N/A

Application Note: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Predicted Molecular Weight: N/A

Isoform: N/A

Purification: >95%

Clonality: Recombinant Monoclonal

Clone: N/A

Isotype: IgG1

Conjugate: Unconjugated

Physical State: N/A

Buffer: PBS buffer pH 7.5

Concentration: N/A

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4°C short term (1-2 weeks) . Store at -20 °C 12 months. Store at -80°C long term.

Additional Names: BMS-986253, HuMax-IL8, HuMax-Inflam/MDX018, IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; SCYB8

Protein Accession: P10145

User Note: For research use only .

Background: HuMax-IL8 (BMS-986253) is a novel fully human monoclonal antibody that binds to and inhibits IL-8, a chemokine that promotes immune escape and tumor progression. Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2) . IL-8 (6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8 (5-77) has increased activity on neutrophil activation and IL-8 (7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8 (1-77), respectively.

Loading Controls: N/A

Source: CHO cells

Purity: >95%

CAS: N/A

Shipping Condition: N/A